Ace assassin Frank Kitchen is double crossed by gangsters and falls into the hands of rogue surgeon known as The Doctor who turns him into a woman. The hitman, now a hitwoman, sets out for revenge, aided by a nurse named Johnnie who also has secrets.
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After finding an ad online for “video work,” Sara, a video artist whose primary focus is creating intimacy with lonely men, thinks she may have found the subject of her dreams. She drives to a remote house in the forest and meets a man claiming to be a serial killer. Unable to resist the chance to create a truly shocking piece of art, she agrees to spend the day with him. However, as the day goes on, she discovers she may have dug herself into a hole from which she can’t escape.
Based on the real-life Richard Speck murders, amoral, nearly psychotic killer Warren Stacey (Gene Davis) is a serial killer who has murdered a number of women; he stabs them while they are naked to minimize leaving any physical evidence. Police detective Leo Kessler (Charles Bronson) is convinced of Stacey’s guilt and, over the objections of his partner, plants evidence to get him behind bars. When Stacey is released on a technicality, he threatens to go after Kessler and his family, leaving Kessler to defend himself against a killer with little help from the police.
World renowned journalist Sara Ogden is traversing the world in pursuit of carriers of a fatally dangerous “Stamp of Cain” in order to prevent seemingly unrelated events such as mass murders, turmoil, revolutions and chaos. She doesn’t even suspect how close she is to the edge of the abyss, when in her search she ends up in Belarus to meet face to face with the one, whom she has been searching for her entire life.